METABOLIC ENGINEERING OF TYPE III PKS FOR OVER PRODUCTION OF SECONDARY METABOLITES IN HETEROLOGOUS HOST SYSTEM

Microbial natural products have a significant role in the medical industry because of their anticancer, antimicrobial and anti-cholesterol activities. Polyketides are one of the important class of biologically active natural products. These polyketides are formed by the polyketide synthases (PKSs). There are three types of PKSs named as a type I, type II and type III. Structure and mechanism properties of all three types are closely related. Because of the diverse bio functionality and commercial application, synthesis of polyketides in heterologous host system becomes essential for mass scale production. There are some factors which have a great impact on the production of polyketides in the heterologous system. In recent years, it was found that metabolic engineering, biosynthesis pathways and related system has been used to enhance the production of polyketides to the heterologous host system.